KMID : 1123920080220030666
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Korean Journal of Oriental Physiology and Pathology 2008 Volume.22 No. 3 p.666 ~ p.671
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Endothelium Dependent Vasorelaxant Action of ChungGongGo Extract on Arterial Contraction in Rabbit
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Oh Chul
Kim Ho-Hyun Ko Heung
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Abstract
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This study was undertaken to define the effect of ChungGongGo extract on norepinephrine-induced arterial contraction in rabbit. In order to investigate the effect of ChungGongGo extract on rabbit¡¯s contracted vascular ring detached from common carotid artery, vascular ring with intact or damaged endothelium was used for the experiment using organ bath. To analyze the mechanism of ChungGongGo extract-induced relaxation, ChungGongGo extract was infused into contracted vascular ring which had been pretreated by -nitro-L-arginine(L-NNA), Methylene blue(MB), and was infused into contracted vascular ring induced by NE or KCl after treatment of ChungGongGo in -free solution. The results were as follows: ChungGongGo extract had an effective relaxation to the contracted vascular ring by NE in 1.0mg/ml and 0mg/ml level. ChungGongGo extract had an effective relaxation to the intact endothelium vascular ring, but when endothelium was removed, vascular ring did not relax. ChungGongGo extract-induced relaxation was inhibited by the pretreatment of L-NNA and MB. Pretreatment of ChungGongGo extract inhibit the contraction by influx of extra- in contracted vascular ring induced by NE in -free solution. As mentioned above, we suggest that ChungGongGo relaxes vascular ring through suppress influx of extra-cellular by the action of nitric oxide from endothelium.
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KEYWORD
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ChungGongGo, endothelium, Nitric oxide
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